Additional studies enriched with patients without HLH who have conditions associated with T-cell activation, such as lymphoma and autoimmune lymphoproliferative syndrome, are needed. Serum sIL-2r is a sensitive test for diagnosis of adult HLH, but is not as specific as previously reported in children. Levels above 10 000 U/mL were not associated with worse prognosis in patients with HLH. Higher mean sIL-2r levels were seen in malignancy-associated HLH (20 241 U/mL) compared with infection-associated HLH and macrophage activation syndrome (97 U/mL, respectively P <. Although there was a large indeterminate range for sIL-2r, a level of 2400 U/mL or less was helpful for ruling out HLH (sensitivity, 100%), and more than 10 000 U/mL was helpful for ruling in HLH (specificity, 93%). The optimal threshold for sIL-2r was 2515 U/mL (sensitivity, 100% specificity, 72.5%). The receiver operating characteristic curve demonstrated that sIL-2r is a good to excellent diagnostic test for adult HLH, with an area under the curve (AUC) of 0.90 (95% confidence interval, 0.83-0.97) compared with AUC 0.78 (95% confidence interval, 0.67-0.88) for ferritin. There were 38 patients with HLH and 40 with a non-HLH diagnosis (such as sepsis, liver disease, histiocyte disorders, autoimmune disease, leukemia, or lymphoma). Serum sIL-2r levels were measured by enzyme-linked immunosorbent assay (adult reference range, 241-846 U/mL). We conducted a single-center retrospective study of 78 consecutive adults who had sIL-2r measured for suspected HLH. We have curated a list of some shocking as well as eye-opening collaboration statistics that’ll make rethink how you think about collaboration in the first place.Serum soluble interleukin-2 receptor (sIL-2r) is an important disease marker in hemophagocytic lymphohistiocytosis (HLH), but there are no published data on its diagnostic value in adults. If you still need convincing about the importance of collaboration and teamwork in the workplace and how profoundly it can impact your bottom line, don’t worry, we got this. It is shocking that companies still communicate and collaborate over email and have not adopted cloud collaboration tools like Bit to increase their productivity.